Pain relief induced by repetitive transcranial magnetic stimulation of precentral cortex

Chronic electrical stimulation of the precentral (motor) cortex using surgi cally implanted electrodes is performed to treat medication-resistant neuro genic pain. The goal of this placebo-controlled study was to obtain such an talgic effects by means of a non-invasive cortical stimulation using repeti tive transcranial magnetic stimulation (rTMS). Eighteen patients with intra ctable neurogenic pain of various origins were included and underwent a 20 min session of either 10 Hz, 0.5 Hz or* sham rTMS over the motor cortex in a random order. A significant decrease in the mean pain level of the series was obtained only after 10 Hz rTMS. This study shows that a transient pain relief can be induced by 10 Hz rTMS of the motor cortex in some patients s uffering from chronic neurogenic pain. NeuroReport 12:2963-2965 (C) 2001 Li ppincott Williams & Wilkins.