Antagonists of the tachykinin receptors, which have been most widely u
sed in scientific investigations during the past decade (up to 1995 in
clusive), are reviewed. The structures and peculiar characteristics of
peptide and nonpeptide compounds of this class are described. Applica
tions of these antagonists in the search for new subtypes of tachykini
n receptors and for structure-function studies are discussed.