THE SYNTHESIS OF TRITERPENE 2-DEOXY-ALPHA -D-HEXOPYRANOSIDES FROM GLYCALS AND THEIR EFFECT ON REPARATIVE PROCESSES

Authors
BALTINA LA FLEKHTER OB VASILEVA EV DAVYDOVA VA ISMAGILOVA AF ZARUDII FS TOLSTIKOV GA
Citation
La. Baltina et al., THE SYNTHESIS OF TRITERPENE 2-DEOXY-ALPHA -D-HEXOPYRANOSIDES FROM GLYCALS AND THEIR EFFECT ON REPARATIVE PROCESSES, Bioorganiceskaa himia, 23(6), 1997, pp. 512-518
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
23
Issue
6
Year of publication
1997
Pages
512 - 518
Database
ISI
SICI code
0132-3423(1997)23:6<512:TSOT2->2.0.ZU;2-L
Abstract
Triterpene 2-deoxy-alpha-D-hexopyranosides were synthesized by the gly cosylation of oleanane triterpene alcohols with D-glucal and D-galacta l acetates in the presence of di(sym-collidine)iodonium perchlorate wi th subsequent deiodination and deacetylation of the resulting 2-deoxy- 2-iodo-alpha-D-glycosides. 2-Deoxy-alpha-D-arabino- and -lyxo-hexopyra nosides of methyl glycyrrhetinate demonstrated pronounced antiulcer ac tivity and stimulated reparative skin regeneration in rats more effect ively than glycyrrhizic acid and methyluracil.