Convenient approaches to 4-trifluoromethylpyridine

Authors
Jiang, B Xiong, WN Zhang, XB Zhang, FJ
Citation
B. Jiang et al., Convenient approaches to 4-trifluoromethylpyridine, ORG PROC R, 5(5), 2001, pp. 531-534
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC PROCESS RESEARCH & DEVELOPMENT
ISSN journal
10836160 → ACNP
Volume
5
Issue
5
Year of publication
2001
Pages
531 - 534
Database
ISI
SICI code
1083-6160(200109/10)5:5<531:CAT4>2.0.ZU;2-I
Abstract
A number of approaches to the synthesis of 2-chloro- and 2,6-dichloro-4-tri fluoromethylpyridine are described. The first method for 2-chloro- and 2,6- dichloro-4-trifluoromethylpyridine is based on commercially available ethyl trifluoroacetate. An alternative access to 2,6-dichloro-4-trifluoromethyl pyridine uses trifluoroacetaldehyde as starting material. 2-Chloro-4-triflu oromethylpyridine is prepared from ethyl(trifluoroacetylvinyl)-ether in two steps.