Antiinflammatory activity from aerial parts of Baccharis medullosa, Baccharis rufescens and Laennecia sophiifolia in mice

The antiinflammatory activities of ten organic extracts from the aerial par ts of Baccharis medullosa DC., Baccharis rufescens S. and Laennecia sophiif olia (Kunth) G. L. Nesom were investigated in mice subjected to carrageenan induced paw oedema. Intraperitoneally administered organic extracts given at doses equivalent to 80 mg/kg of material inhibited the acute phases of i nflammation in this model. Our results indicate that the most effective ext racts were: n-hexane (1) from B. medullosa, acetone (V) and chloroform (VII ) from L sophiifolia, and acetone (VIII) and chloroform (X) from B. rufesce ns. All exerted the strongest effect at 5 h after injection of the phlogist ic agent. Copyright (C) 2001 John Wiley & Sons, Ltd.