M. Lujan et al., Prostate specific antigen density. Is there a role for this parameter whenscreening for prostate cancer?, PROSTATE C, 4(3), 2001, pp. 146-149
The objective of this paper is to validate prostate specific antigen (PSA)
density (PSAD) routine use to enhance PSA specificity in men with normal di
gital rectal examination and intermediate PSA values. It is a retrospective
study of 235 men from a prostate cancer (PCa) screening program. All of th
em presented PSA values between 4 and 10 mg/ml, normal digital rectal exami
nation, and a transrectal ultrasound (TRUS) guided biopsy available (PSA gr
eater than or equal to 4 ng/ml as the sole criterion for biopsy). Multivari
ate analysis failed to demonstrate higher PSAD values in men with PCa. PSAD
cutoff points higher than 0.07 ng/ml per cc were considered as unacceptabl
e, with less than 95% sensitivity. When a cutoff point of 0.15 was consider
ed, as many as, 30.6% of the cancers were missed. In conclusion we cannot r
ecommend the use of this parameter for the above mentioned purpose.