Validity of PSA, free/total PSA ratio and complexed/total PSA ratio measurements in men with acute urinary retention

Authors
Sriprasad, S Dew, TK Muir, GH Thompson, PM Mulvin, D Choi, WH Dickinson, IK Sherwood, RA
Citation
S. Sriprasad et al., Validity of PSA, free/total PSA ratio and complexed/total PSA ratio measurements in men with acute urinary retention, PROSTATE C, 4(3), 2001, pp. 167-172
Citations number
21
Categorie Soggetti
Urology & Nephrology
Journal title
PROSTATE CANCER AND PROSTATIC DISEASES
ISSN journal
13657852 → ACNP
Volume
4
Issue
3
Year of publication
2001
Pages
167 - 172
Database
ISI
SICI code
1365-7852(2001)4:3<167:VOPFPR>2.0.ZU;2-A
Abstract
The reliability of serum prostate specific antigen (PSA) measurements in me n with acute urinary retention is unclear. Total PSA, free and complexed PS A were measured, and the free/total (f/t) PSA and complexed/total (c/t) PSA ratios calculated, prior to catheterisation and at 48 and 72 h post-cathet erisation in 39 men with acute retention. Subsequent histology showed 12 pa tients had prostate cancer and 27 benign prostatic hypertrophy. Serum free and total PSA fell following catheterisation, while complexed PSA rose duri ng the first 48 h then subsequently fell. The f/t PSA and c/t PSA ratios pr ovided the best discrimination at 48-72 h with 100% sensitivity and 75-82% specificity.