Positron emission tomography (PET) scanning has evolved over the past 40 ye
ars from a tool predominantly used for research, to a valued clinical, imag
ing modality. Current PET scanners must perform high-quality, whole-body, a
nd brain PET. There are several levels of PET devices, from the dedicated,
high-end scanners to the hybrid PET/single photon emission CT (SPECT) syste
ms, and offer varying levels of performance. The next generation of PET sca
nners most likely will involve the use of new scintillating materials. Ther
e also is a growing interest in dedicated devices for specific applications
such as high-resolution scanners for imaging small animals.