D. Duro et al., ALTERATIONS OF THE PUTATIVE TUMOR-SUPPRES SOR GENE P16 MTS1 IN HUMAN HEMATOLOGICAL MALIGNANCIES/, Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie, 317(10), 1994, pp. 913-919
The chromosome band 9p21-22 is frequently rearranged or deleted in a v
ariety of tumors including hematological malignancies. This supports t
he notion of a tumor suppressor gene in this chromosome region. Indeed
, the p16/MTS1 gene encoding a cyclin-dependent kinase (CDK) inhibitor
has been shown to be frequently deleted and/or inactivated by nonsens
e mutations in a number of tumors. We have examined 98 DNA samples fro
m blood, bone marrow cells and lymph node biopsies of patients with le
ukemia (ALL and AML) or lymphoma (follicular lymphoma and T-cell lymph
oma), using Southern blot hybridization and a p16/MTS1-specific probe.
Molecular abnormalities, mainly homozygous deletions, were found prin
cipally in ALL (8 out of 22 patients), much less frequently in AML (2/
32) and lymphoma (2/32). While these data argue in favor of a large in
volvement of p16/MTS1 in ALL, AML and lymphomas appear to be less freq
uently implicated.