Acid-base balance and gastric secretion of hydrocarbonate ions in ulcer patients

Aim. To study acid-base balance (ABB) of the organism, gastric secretion of hydrocarbonate (HCO3-) in ulcer patients and to examine their relationship s. Material and methods. ABB in capillary or venous blood before and after los ec and famotidine treatment and gastric secretion of HCO3- were studied in 72 patients with utter. Results. It was found that patients with gastroduodenal ulcer have metaboli c, less frequently hypercapnic acidosis with suppressed gastric secretion o f HCO3-. This entails abnormal neutralization of the hydrochloric acid imit ating high acidity of the gastric juice. HCO3- secretion is inversely propo rtional to pH. H2-blockers normalize ABB in ulcer patients while losec eith er stimulates acidosis or transforms one kind of acidosis into another. Conclusion. A BB and gastric secretion of HCO3- are related. Acidosis in ul cer patients leads to reduction of HCO3- production and intensification of hydrochloric acid secretion.