Interleukines in chronic viral hepatitis

Aim. To estimate interleukines levels in chronic hepatitis (CH) in respect to CH etiological factor, activity and stage. Material and methods. Enzyme immunoassay (kits from proteinovy Kontur, St-P etersburg) determined levels of IL-1beta, IL-4, IL-6 and TNF-alpha in the p eripheral blood of 250 patients with chronic hepatitis C (CHC), B (CHB), D (CHD) and G (CHG). Results. IL concentrations in chronic viral hepatitis depend on etiological factor (CHC, CHB, CHD, CHG), activity (high, moderate, low), stage (chroni c hepatitis, cirrhosis). IL occur in high quantities it? CHC, in moderate c oncentrations in CHB and in minimal ones in CHG. Maximal IL levels were obs erved in high hepatitis activity at the stage of hepatic cirrhosis. TNF-alp ha and IL-4 concentrations rose more frequently and higher than IL-6 and IL -1beta (43 and 34%, tip to 315 pg/ml and 256 pg/ml, respectively).