Some hormonal indices in patients with acute renal failure on hemofiltration

Aim. To study hormonal aspects of hemofiltration (HF) in acute renal failur e (ARF). Material and methods. Hydrocortisone (TIC), thyroxine (T4), triiodothyronin e (T3), TSH, thyrocalcitonine (TC), PTH, insulin (1), C-peptide (CP), STH, beta-endorphine (BE) were examined for plasma content, elimination with fil trate, sifting rate, filtration clearance in 29 patients with oliguric ARF (IS finales and 11 females) aged 12-62 years. 19 patients underwent intermi ttent HF (rate 145.2 +/- 9.2/27-260/ml/min, volume 1.02 +/- 0.20/0.45-1.43/ ). 10 patients received continuous HF (rate 25.9 +/- 2.3 l/day or 0.36 +/- 0.05/0.17-0.95/). The hormones were measured with radioimmunoassay. The res ults were processed with variate statistics using Student's criterium. Results. Oliguria was associated with high plasma levels of HC, PTH TC, 1, CP; normal levels of TSH and STH, low ones of T4, T3 and BE. Intermittent H F led to an increased plasma concentrations of HC, T4, 1, CP, decreased one of PTH, while TC, TSH, STH and T3 remained unchanged. The filtration rate of the hormones leas different. The elimination was greatest for HC, T4, T3 , BE. Concentration of the former three in the filtrate surpassed that in b lood plasma. Conclusion. Besides intensive elimination of the hormones with low molecula r mass (HC, T4, T3), HF causes elimination of appreciable quantities of BE, PTH, 1, CT and, probably, other peptide hormones. Plasma levels of hormone s did not reflect their elimination with filtrate.