Synthesis of haptens for the development of immunoassays for the monitoring of intracellular anti-HIV nucleosides and nucleotides

Authors
Brossette, T Klein, E Creminon, C Grassi, J Mioskowski, C Lebeau, L
Citation
T. Brossette et al., Synthesis of haptens for the development of immunoassays for the monitoring of intracellular anti-HIV nucleosides and nucleotides, TETRAHEDRON, 57(38), 2001, pp. 8129-8143
Citations number
52
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
38
Year of publication
2001
Pages
8129 - 8143
Database
ISI
SICI code
0040-4020(20010917)57:38<8129:SOHFTD>2.0.ZU;2-1
Abstract
A series of nine modified dideoxynucleosides and dideoxynucleotides has bee n synthesized for preparing antigenic conjugates with keyhole lympet haemoc yanin in order to produce specific antibodies, and develop immunoassays. De rivatives of ddI, ddA, d4T, 3TC, and the corresponding 5 ' -O-monophosphate s were designed incorporating an amino spacer at the base for conjugation w ith the proteinic antigenic carrier. (C) 2001 Elsevier Science Ltd. All rig hts reserved.