Deprotection of N-alloc amines by Pd(0)/DABCO - an efficient method for insitu peptide coupling of labile amino acids

Authors
Zorn, C Gnad, F Salmen, S Herpin, T Reiser, O
Citation
C. Zorn et al., Deprotection of N-alloc amines by Pd(0)/DABCO - an efficient method for insitu peptide coupling of labile amino acids, TETRAHEDR L, 42(40), 2001, pp. 7049-7053
Citations number
45
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
40
Year of publication
2001
Pages
7049 - 7053
Database
ISI
SICI code
0040-4039(20011001)42:40<7049:DONABP>2.0.ZU;2-W
Abstract
A highly, efficient one-pot deprotection peptide coupling protocol of N-All oc amino acids with activated N-Boc or N-Fmoc amino acids was developed in solution and on solid phase. DABCO was found to be especially effective for the deprotection of the N-Alloc group, resulting in short reaction times ( 10 20 min) and allowing the coupling of amino acids that are unstable in un protected forms. (C) 2001 Elsevier Science Ltd. All rights reserved.