Solid-phase extraction (SPE) materials are a promising and innovative appli
cation of molecularly imprinted polymers (MIPs). These polymers allow certa
in analytes to be selectively extracted from complex matrices without matri
x interference. The applications described in this article include the mole
cularly imprinted SPE (MISPE) of several kinds of analytes of biological, p
harmaceutical and environmental interest. To ensure selectivity emphasis is
placed on synthetic considerations and the various steps in the extraction
process. Finally, we also report on recent advances in this technique. (C)
2001 Elsevier Science B.V. All rights reserved.