Phylogenetic analysis of small ruminant lentiviruses from Southern Brazil

Citation
Ap. Ravazzolo et al., Phylogenetic analysis of small ruminant lentiviruses from Southern Brazil, VIRUS RES, 79(1-2), 2001, pp. 117-123
Citations number
34
Categorie Soggetti
Microbiology
Journal title
VIRUS RESEARCH
ISSN journal
01681702 → ACNP
Volume
79
Issue
1-2
Year of publication
2001
Pages
117 - 123
Database
ISI
SICI code
0168-1702(20011105)79:1-2<117:PAOSRL>2.0.ZU;2-Z
Abstract
The first lentivirus isolated from sheep in Brazil was analysed phylogeneti cally. Evolutionary trees of the proviral 597 nucleotide gag and 432 nucleo tide pol sequences obtained by the maximum likelihood method demonstrated t hat the sheep isolate clustered with prototype Maedi Visna virus whereas th ree lentiviruses isolated from goats in the same geographic region were clo se to caprine arthritis encephalitis prototypes. A subsequent comparison of sequence data of these viruses with those contained in the EMBL sequence d atabase revealed that, in contrast to caprine prototypic viruses, all proto typic Maedi Visna viruses contain a deletion of six nucleotides in the gag gene resulting in the deletion of two residues in the central region of cap sid protein. This deletion may be a useful marker in the analysis of small ruminant lentiviruses, especially when considering possible transmission of lentiviruses between sheep and goats. (C) 2001 Elsevier Science B.V. All r ights reserved.