4-{3-[(4-fluorobenzylidene)amino]-2-oxo-1,3-oxazolidin-5-ylmethyl}morpholine

Citation
R. Kruszynski et al., 4-{3-[(4-fluorobenzylidene)amino]-2-oxo-1,3-oxazolidin-5-ylmethyl}morpholine, ACT CRYST E, 57, 2001, pp. O386-O388
Citations number
12
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE
ISSN journal
16005368 → ACNP
Volume
57
Year of publication
2001
Part
5
Pages
O386 - O388
Database
ISI
SICI code
1600-5368(200105)57:<O386:4>2.0.ZU;2-C
Abstract
A series of derivatives of 3-amino-2-oxazolidinone have been prepared. The 5-morpholinomethyl-3-(4-chlorobenzylideneamino)-2-oxazolidinone derivative is a potential psychotropic drug. Preliminary clinical data showed that the compound exhibits antidepressive activity in humans. The molecular geometr y of the title compound, C15H18FN3O3, is similar to 5-morpholinomethyl-3-(4 -chlorobenzylideneamino)-2-oxazol-idinone. Two atoms of the title compound are disordered so that two different conformations of the oxazolidinone rin g were found; one is a twist and the other is an envelope conformation. The crystal structure of title compound is formed by weak intermolecular C-H . . .O hydrogen bonds resulting in a two-dimensional infinite hydrogen-bond network.