MODELING OF GROWTH OF CORYNEBACTERIUM-GLUTAMICUM UNDER BIOTIN LIMITATION

One of the prerequisites for the successful production of L-glutamic a cid with Corynebacterium glutamicum is the realization of adequate gro wth under biotin limiting conditions. The intracellular biotin content , i.e. the specific biotin concentration is shown to be the limiting f actor for growth in this fermentation process. Modelling of growth is then examined with logistic models and Monod kinetics. For the descrip tion of the lag phase different extensions of kinetics are compared re spectively tested and two new mathematical functions suggested for thi s purpose.