A point mutation in CD45 may be associated with an increased risk of HIV-1infection

Authors
Tchilian, EZ Wallace, DL Dawes, R Imami, N Burton, C Gotch, F Beverley, PCL
Citation
Ez. Tchilian et al., A point mutation in CD45 may be associated with an increased risk of HIV-1infection, AIDS, 15(14), 2001, pp. 1892-1894
Citations number
11
Categorie Soggetti
Immunology
Journal title
AIDS
ISSN journal
02699370 → ACNP
Volume
15
Issue
14
Year of publication
2001
Pages
1892 - 1894
Database
ISI
SICI code
0269-9370(20010928)15:14<1892:APMICM>2.0.ZU;2-M
Abstract
The CD45 antigen is essential for normal antigen receptor-mediated signalli ng in lymphocytes, and different patterns of splicing of CD45 are associate d with distinct functions in lymphocytes. Here we show that abnormal CD45 s plicing caused by a C77G transversion in exon A of the gene encoding CD45 ( PTPRC) is associated with increased susceptibility to HIV-1 infection.