Economic assessment of rheolytic thrombectomy versus intracoronary urokinase for treatment of extensive intracoronary thrombus: Results from a randomized clinical trial

Background Despite advances in mechanical and pharmacologic therapy, thromb us-containing lesions are at high risk for adverse events and remain a chal lenging subset for percutaneous coronary revascularization. Recently, rheol ytic thrombectomy with the AngioJet device has been shown to safely remove intracoronary thrombus, but the overall cost-effectiveness of this techniqu e is unknown. Methods We determined in-hospital and 1-year follow-up costs for 349 patien ts with overt intracoronary thrombus who were randomly assigned to treatmen t with intracoronary urokinase (6- to 30-hour infusion followed by definiti ve revascularization; n = 169) or immediate thrombectomy with the AngioJet device (n = 180) as part of the Vein Graft AngioJet Study (VeGAS) 2 trial. Catheterization laboratory costs were based on measured resource utilizatio n and 1998 unit costs, whereas all other costs were estimated from hospital charges and cost center-specific cost-to-charge ratios. Results Compared with urokinase, rheolytic thrombectomy reduced the inciden ce of periprocedural myocardial infarction (12.8% vs 30.3%, P < .001) and m ajor hemorrhagic complications (2.8% vs 11.2%, P < .001) and shortened leng th of stay by nearly 1 day (4.2 vs 4.9 days; P = .02). As a result, AngioJe t treatment reduced procedural costs, hospital room/nursing costs, and anci llary costs with resulting hospital cost savings of approximately $3500 per patient during the initial hospitalization ($15,311 vs $18,841, P < .001). These cost savings were maintained at 1 year of follow-up ($24,389 vs $29, 109, P < .001). Conclusions Compared with standard treatment with intracoronary urokinase, rheolytic thrombectomy both improves clinical outcomes and reduces overall medical care costs for patients with extensive intracoronary thrombus.