Hemangioblastoma arising in the skin

Hemangioblastomas are intracranial and intraspinal tumors arising sporadica lly or in patients with von Hippel-Lindau disease. To date, hemangioblastom as have not been described in the skin. Proliferating clear cells with a va riable vascular component are found histologically. These clear cells stain for neuron-specific enolase but not cytokeratin or epithelial membrane ant igen, allowing them to be differentiated from metastatic renal cell carcino ma.