SUCCESSFUL REVERSAL OF DIABETES BY SINGLE-DONOR ISOLOGOUS ISLET TRANSPLANTATION IN A MOUSE MODEL

Authors
LEOW CK GRAY DWR MORRIS PJ
Citation
Ck. Leow et al., SUCCESSFUL REVERSAL OF DIABETES BY SINGLE-DONOR ISOLOGOUS ISLET TRANSPLANTATION IN A MOUSE MODEL, Cell transplantation, 6(4), 1997, pp. 429-430
Citations number
4
Categorie Soggetti
Cell Biology",Transplantation
Journal title
Cell transplantation → ACNP
ISSN journal
09636897
Volume
6
Issue
4
Year of publication
1997
Pages
429 - 430
Database
ISI
SICI code
0963-6897(1997)6:4<429:SRODBS>2.0.ZU;2-5
Abstract
A method for isolating mouse islets which consistently gives a high yi eld with good purity is described. Using a bovine serum albumin gradie nt, the mean yield of islets per pancreas is 425 (SEM +/- 15) with a c onsistent purity of over 90%. Single donor to single recipient of isle ts transplanted under the renal capsule restores normoglycemia in the diabetic recipients within 2 to 5 days of transplantation. (C) 1997 El sevier Science Inc.