DISTRIBUTION OF ABO GENOTYPES AND ALLELE FREQUENCIES IN A KOREAN POPULATION

The genotypes of the ABO blood group system were investigated in Korea n living in Kangwon-Do area by PCR-RFLP analysis of the seven polymorp hic nucleotide positions 261, 467, 526, 646, 703, 796 and 803 of the c DNA from A, transferase. In 253 unrelated Korean individuals, 15 genot ypes were found and the allele frequencies of A(Pro), A(Leu), B, O(T) and O(A) were 0.022, 0.209, 0.209, 0.360 and 0.200, respectively, with no deviation from Hardy-Weinberg expectations (chi(2)=2.145, d.f.=6, 0.90<p<0.95). As for the distribution of allele frequencies, a signifi cant difference was noticed between the Korean and a Japanese (chi(2)= 30.87, d.f.=4, p<0.001) and a German (chi(2)=127.76,d.f.=4, p < 0.001) populations.