Reversible posterior leukoencephalopathy syndrome following CHOP chemotherapy for diffuse large B-cell lymphoma

A 63-year-old female with stage IE diffuse large B-cell lymphoma developed reversible posterior leukoencephalopathy syndrome (RPLS) following CHOP che motherapy, with typical clinical and radiological findings. RPLS is a rare neurological syndrome characterised by visual disturbances, seizures, heada ches and altered conscious level which has been associated with malignant h ypertension, pre-eclampsia and some drugs, including ciclosporin. It has no t been previously reported following CHOP chemotherapy. Alternative treatme nt should be considered for patients who develop this rare complication.