Evaluation of cross-protection afforded by a Salmonella Choleraesuis vaccine against Salmonella infections in pigs under field conditions

This field study investigated the efficacy of a Salmonella Choleraesuis liv e vaccine (Argus SC(TM)) to reduce the number of infections with Salmonella . Twelve groups of about 380 pigs each were randomly allocated to either va ccination M or no vaccination (C). The vaccine was applied orally at 3 and 16 weeks. Forty pigs per group were blood sampled at 3, 10, 16, and 24 week s to detect possible antibodies against Salmonella. The prevalence of Salmo nella in the lymph nodes was the major variable. In the V groups, only 0.6 % of the lymph nodes were positive, whereas 7.2 % were positive in the C gr oups (p < 0.001). The percentage of seropositive pigs at 24 weeks (cut-off OD > 10) was 26 % and 9 % in the V and C groups, respectively (p < 0.001). The present study documented that vaccination with a live modified S. Chole raesuis vaccine is a useful tool to lower the prevalence of Salmonella in s wine herds.