Aptamers that bind to the antibiotic moenomycin A

Authors
Schurer, H Stembera, K Knoll, D Mayer, G Blind, M Forster, HH Famulok, M Welzel, P Hahn, U
Citation
H. Schurer et al., Aptamers that bind to the antibiotic moenomycin A, BIO MED CH, 9(10), 2001, pp. 2557-2563
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
10
Year of publication
2001
Pages
2557 - 2563
Database
ISI
SICI code
0968-0896(200110)9:10<2557:ATBTTA>2.0.ZU;2-5
Abstract
Nuclease-resistant moenomycin-binding aptamers with dissociation constants in the range of 300 to 400 nM have been selected. Competition experiments h ave demonstrated that these aptamers recognize a disaccharide analogue of m oenomycin. The results offer the opportunity of setting up a selective and sensitive assay for identifying moenomycin biosynthetic precursors. (C) 200 1 Elsevier Science Ltd. All rights reserved.