Topical calcipotriol as monotherapy and in combination with psoralen plus ultraviolet A in the treatment of vitiligo

Background Recent advances in the pathophysiology of vitiligo have demonstr ated defective calcium homeostasis in depigmented skin. 1,25-Dihydroxyvitam in D-3 may be involved in the regulation of melanin synthesis, and receptor s for 1,25-dihydroxyvitamin D-3 have been demonstrated on melanocytes. Objectives We conducted an open study to determine the efficacy and tolerab ility of calcipotriol cream as monotherapy and in conjunction with psoralen plus ultraviolet A (PUVA) in the treatment of vitiligo. Methods Twenty-six patients with vitiligo affecting 5-40% of their skin wer e recruited. Twenty-two were treated with twice-daily topical calcipotriol monotherapy (50 mug g(-1)) and four were placed on combination treatment wi th twice-daffy topical calcipotriol 50 mug g(-1) in conjunction with topica l or oral 8-methoxypsoralen PUVA three times weekly. Results Treatment was well tolerated at all sites and no adverse effects we re reported. After a therapy time of 3-9 months (mean 6 months), 77% (17 of 22) of those treated with monotherapy showed 30-100% improvement, and thre e of the four patients on combination treatment showed good response. Conclusions Topical calcipotriol appears to be an effective and well-tolera ted treatment for vitiligo and can be safely used in conjunction with PUVA, but controlled studies are necessary to exclude the possibility of spontan eous repigmentation.