Delivering adjuvant chemotherapy to women with early-stage breast carcinoma - Current patterns of care

Citation
Bk. Link et al., Delivering adjuvant chemotherapy to women with early-stage breast carcinoma - Current patterns of care, CANCER, 92(6), 2001, pp. 1354-1367
Citations number
29
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER
ISSN journal
0008543X → ACNP
Volume
92
Issue
6
Year of publication
2001
Pages
1354 - 1367
Database
ISI
SICI code
0008-543X(20010915)92:6<1354:DACTWW>2.0.ZU;2-S
Abstract
BACKGROUND. Variations in practice patterns are markers for the quality of patient care in general medicine, but little is known about variation in ca re delivered to cancer patients. This study's purpose was to describe chemo therapy use, variations in chemotherapy delivery, and the incidence of comp lications in community practice settings. METHODS. Data describing adjuvant chemotherapy for patients with early-stag e breast carcinoma (ESBC) were collected from an ongoing Oncology Practice Pattern Study at 13 large managed care, academic, and community practices ( 1111 patients). Data collection included information about diagnoses and ad juvant chemotherapy treatments, laboratory results, supportive care, compli cations, and treatment modifications. RESULTS. The median patient age was 50 years, and most patients had zero to three positive lymph nodes. Chemotherapy regimens consisting of cyclophosp hamide, methotrexate, and 5-fluororacil (CMF) and of doxorubicin and cyclop hosphamide (AC) accounted for 76% of the adjuvant therapies used. Overall, 30% of patients had delivered average relative dose intensities less than o r equal to 85% of the referenced targets. Delivered summation dose intensit ies (SDIs) frequently were well below targeted SDIs. Neutropenia-related do se modifications occurred for 27.6% of patients and recurred with a 60.7% r ate. AC was the regimen delivered with a dose intensity closest to the refe renced target. However, patients who were treated with AC regimens and with regimens consisting of cyclophosphamide, doxorubicin, and 5-fluorouracil h ad significantly higher rates of chemotherapy-related complications compare d with patients who were treated with CMF regimens in the most recent treat ment years. CONCLUSIONS. Adjuvant chemotherapy for patients with ESBC frequently is not administered as referenced in off-protocol community settings. Variation i n the delivered SDI raises concerns about potential treatment outcomes and warrants strategies to identify patients who are at risk for complications early in therapy. (C) 2001 American Cancer Society.