Bk. Link et al., Delivering adjuvant chemotherapy to women with early-stage breast carcinoma - Current patterns of care, CANCER, 92(6), 2001, pp. 1354-1367
BACKGROUND. Variations in practice patterns are markers for the quality of
patient care in general medicine, but little is known about variation in ca
re delivered to cancer patients. This study's purpose was to describe chemo
therapy use, variations in chemotherapy delivery, and the incidence of comp
lications in community practice settings.
METHODS. Data describing adjuvant chemotherapy for patients with early-stag
e breast carcinoma (ESBC) were collected from an ongoing Oncology Practice
Pattern Study at 13 large managed care, academic, and community practices (
1111 patients). Data collection included information about diagnoses and ad
juvant chemotherapy treatments, laboratory results, supportive care, compli
cations, and treatment modifications.
RESULTS. The median patient age was 50 years, and most patients had zero to
three positive lymph nodes. Chemotherapy regimens consisting of cyclophosp
hamide, methotrexate, and 5-fluororacil (CMF) and of doxorubicin and cyclop
hosphamide (AC) accounted for 76% of the adjuvant therapies used. Overall,
30% of patients had delivered average relative dose intensities less than o
r equal to 85% of the referenced targets. Delivered summation dose intensit
ies (SDIs) frequently were well below targeted SDIs. Neutropenia-related do
se modifications occurred for 27.6% of patients and recurred with a 60.7% r
ate. AC was the regimen delivered with a dose intensity closest to the refe
renced target. However, patients who were treated with AC regimens and with
regimens consisting of cyclophosphamide, doxorubicin, and 5-fluorouracil h
ad significantly higher rates of chemotherapy-related complications compare
d with patients who were treated with CMF regimens in the most recent treat
ment years.
CONCLUSIONS. Adjuvant chemotherapy for patients with ESBC frequently is not
administered as referenced in off-protocol community settings. Variation i
n the delivered SDI raises concerns about potential treatment outcomes and
warrants strategies to identify patients who are at risk for complications
early in therapy. (C) 2001 American Cancer Society.