Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L.

Authors
Takashi, M Mochida, K Kozuka, M Ito, Y Fujiwara, Y Hashimoto, K Enjo, F Ogata, M Nobukuni, Y Tokuda, H Nishino, H
Citation
M. Takashi et al., Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L., CANCER LETT, 172(2), 2001, pp. 103-109
Citations number
23
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
03043835 → ACNP
Volume
172
Issue
2
Year of publication
2001
Pages
103 - 109
Database
ISI
SICI code
0304-3835(20011030)172:2<103:CCAOCI>2.0.ZU;2-T
Abstract
Capsanthin (1) and related carotenoids (2-7) isolated from the fruits of re d paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting ac tivity with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acet ate (TPA). Among them, capsanthin diester (3) and capsorbin diester (5) sho wed strong inhibitory effects. Furthermore, casanthin (1), capsanthin 3'-es ter (2) and capsanthin 3,3'-diester (3), major carotenoids in paprika, exhi bited potent anti-tumor-promoting activity in an in vivo mouse skin two-sta ge carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiat or and TPA as a promoter. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.