Error-prone DNA polymerases: Novel structures and the benefits of infidelity

Authors
Friedberg, EC Fischhaber, PL Kisker, C
Citation
Ec. Friedberg et al., Error-prone DNA polymerases: Novel structures and the benefits of infidelity, CELL, 107(1), 2001, pp. 9-12
Citations number
17
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL
ISSN journal
00928674 → ACNP
Volume
107
Issue
1
Year of publication
2001
Pages
9 - 12
Database
ISI
SICI code
0092-8674(20011005)107:1<9:EDPNSA>2.0.ZU;2-E
Abstract
Studies on several recently discovered error-prone DNA polymerases reveal n ovel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (transles ion synthesis) of base damage in DNA.