Human migraine models

The need for experimental models is obvious. In animal models it is possibl e to study vascular responses, neurogenic inflammation, c-fos expression et c. However, the pathophysiology of migraine remains unsolved, why results f rom animal studies not directly can be related to the migraine attack, whic h is a human experience. A set-up for investigations of experimental headache and migraine in humans , has been evaluated and headache mechanisms explored by using nitroglyceri n and other headache-inducing agents. Nitric oxide (NO) or other parts of t he NO activated cascade seems to be responsible for the induced headache an d migraine. Perspectives are discussed.