PARP-1: a regulator of genomic stability linked with mammalian longevity

Authors
Burkle, A
Citation
A. Burkle, PARP-1: a regulator of genomic stability linked with mammalian longevity, CHEMBIOCHEM, 2(10), 2001, pp. 725
Citations number
27
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMBIOCHEM
ISSN journal
14394227 → ACNP
Volume
2
Issue
10
Year of publication
2001
Database
ISI
SICI code
1439-4227(20011001)2:10<725:PAROGS>2.0.ZU;2-#
Abstract
Guardian of the genome: Covalent modification of proteins with poly(ADP-rib ose) (see picture), catalysed by the enzyme poly(ADP-ribose) polymerase-1 ( PARP-1), is a rapid cellular response to DNA damage and contributes to geno me stabilization in cells under genotoxic stress. Interestingly, the capaci ty of lymphocytes to produce poly(ADP-ribose) is correlated with the life s pan of mammalian species, thus suggesting a functional role for PARP-1 in l ongevity.