A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation

Authors
Hertweck, C Jarvis, AP Xiang, LK Moore, BS Oldham, NJ
Citation
C. Hertweck et al., A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation, CHEMBIOCHEM, 2(10), 2001, pp. 784
Citations number
28
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMBIOCHEM
ISSN journal
14394227 → ACNP
Volume
2
Issue
10
Year of publication
2001
Database
ISI
SICI code
1439-4227(20011001)2:10<784:AMOBAB>2.0.ZU;2-N
Abstract
Despite the simple structure and widespread occurrence of benzoic acid, its biosynthesis has resisted complete elucidation. However, recent studies re veal that the conversion of cinnamoyl-CoA into benzoyl-CoA (see scheme; R = Ph) can proceed by a route that resembles fatty acid beta -oxidation. Feedi ng studies and sequence analyses show that both pathways not only proceed w ith the same stereochemistry, but are also mechanistically related.