Proteasome inhibitors: from research tools to drug candidates

Authors
Kisselev, AF Goldberg, AL
Citation
Af. Kisselev et Al. Goldberg, Proteasome inhibitors: from research tools to drug candidates, CHEM BIOL, 8(8), 2001, pp. 739-758
Citations number
152
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CHEMISTRY & BIOLOGY
ISSN journal
10745521 → ACNP
Volume
8
Issue
8
Year of publication
2001
Pages
739 - 758
Database
ISI
SICI code
1074-5521(200108)8:8<739:PIFRTT>2.0.ZU;2-0
Abstract
The 26S proteasome is a 2.4 MDa multifunctional ATP-dependent proteolytic c omplex, which degrades the majority of cellular polypeptides by an unusual enzyme mechanism. Several groups of proteasome inhibitors have been develop ed and are now widely used as research tools to study the role of the ubiqu itin-proteasome pathway in various cellular processes, and two inhibitors a re now in clinical trials for treatment of multiple cancers and stroke. (C) 2001 Elsevier Science Ltd. All rights reserved.