The effect of triterpene glycosides on electrical activity changes of identified mollusk neurons

Authors
Kostyuchenko, OV Grishkovets, VI Sobolev, EA Korenyuk, II
Citation
Ov. Kostyuchenko et al., The effect of triterpene glycosides on electrical activity changes of identified mollusk neurons, CHEM NAT CO, 37(1), 2001, pp. 43-46
Citations number
27
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
CHEMISTRY OF NATURAL COMPOUNDS
ISSN journal
00093130 → ACNP
Volume
37
Issue
1
Year of publication
2001
Pages
43 - 46
Database
ISI
SICI code
0009-3130(200101/02)37:1<43:TEOTGO>2.0.ZU;2-T
Abstract
The effect of mono- and bisdesmoside triterpene glycosides on the backgroun d activity of the grape snail Helix pomatia identified neurons was studied. Monodesmoside glycosides at concentrations of 10(-3)-10(-4) M elicit stabl e hyperpolarization of neurons by increasing the membrane permeability for K+ ions. At concentrations of 10(-5)-10(-7) M, they briefly change the neur onal impulse activity. The type of monodesmoside triterpene glycoside activ ity on neurons depends on the structure of the hydrocarbon. The glycoside e ffect on neuron membranes is related to the hemolytic activity.