Ov. Kostyuchenko et al., The effect of triterpene glycosides on electrical activity changes of identified mollusk neurons, CHEM NAT CO, 37(1), 2001, pp. 43-46
The effect of mono- and bisdesmoside triterpene glycosides on the backgroun
d activity of the grape snail Helix pomatia identified neurons was studied.
Monodesmoside glycosides at concentrations of 10(-3)-10(-4) M elicit stabl
e hyperpolarization of neurons by increasing the membrane permeability for
K+ ions. At concentrations of 10(-5)-10(-7) M, they briefly change the neur
onal impulse activity. The type of monodesmoside triterpene glycoside activ
ity on neurons depends on the structure of the hydrocarbon. The glycoside e
ffect on neuron membranes is related to the hemolytic activity.