Preparation of novel enantiopure ferrocenyl-based ligands for asymmetric catalysis

Novel enantiopure ferrocene-based aminophosphine and diphosphine ligands fo r asymmetric catalysts have been developed. In all cases a highly flexible synthetic approach allowed access to ligands with different ferrocenyl back bones and with a variety of functional group patterns. Procedures for the s ynthesis of six families of ligands with either a homo- or heteroannularly bridged ferrocene, ferrocenylmethyl, biferrocene, biferroceno-azepine or fe rrocenyl-aryl framework are described in detail.