Recent developments in asymmetric catalysis

Asymmetric catalysis has long been dominated by C-2-Symmetric bidentate lig ands. More recently, sterically and electronically unsymmetrical ligands ha ve found increasing attention. An important family of these are the phosphi nooxazoline (PHOX) ligands incorporating one P-coordinating and one N-coord inating unit. Important applications of PHOX ligands include Pd-catalyzed a llylic substitution and Ir-catalyzed hydrogenation.