Optical resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline by supercritical fluid extraction

6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) enantiomers were separ ated by supercritical fluid extraction using carbon dioxide. Diastereoisome ric salts were formed from the racemic base with less than one equivalent o f O,O'-di-(4-toluoyl)-(2R,3R)-tartaric acid (DPTTA). Further purification w as achieved by partial salt formation of the enantiomeric mixture with an a chiral acid (HCl) followed by the supercritical fluid extraction of the fre e enantiomers. Chirality 13:568-570, 2001. (C) 2001 Wiley-Liss, Inc.