Coccidioidomycosis in solid organ transplantation

Coccidioidomycosis is an endemic fungal infection of the southwestern Unite d States. Normally a self-limited infection in healthy hosts, coccidioidomy cosis can become a serious complication in patients who have had solid orga n transplantation. Among patients whose solid organ transplantation was com plicated by coccidioidomycosis, the infection has a variety of clinical pre sentations. Disseminated disease is common and has substantial morbidity. P atients at risk for coccidioidal infection should be identified so that ant ifungal prophylactic therapy can be initiated. Treatment options include am photericin B or azoles. Secondary prophylaxis is recommended because relaps e is frequent.