Synaptic plasticity: A molecular memory switch

Authors
Lisman, JE McIntyre, CC
Citation
Je. Lisman et Cc. Mcintyre, Synaptic plasticity: A molecular memory switch, CURR BIOL, 11(19), 2001, pp. R788-R791
Citations number
21
Categorie Soggetti
Experimental Biology
Journal title
CURRENT BIOLOGY
ISSN journal
09609822 → ACNP
Volume
11
Issue
19
Year of publication
2001
Pages
R788 - R791
Database
ISI
SICI code
0960-9822(20011002)11:19<R788:SPAMMS>2.0.ZU;2-J
Abstract
Recent work shows that two molecules with major roles in synaptic plasticit y - CaMKII and the NMDA receptor bind to each other. This binding activates CaMKII and triggers its autophosphorylation. In this state, it may act as a memory switch and strengthen synapses through enzymatic and structural pr ocesses. (C) 2001 Elsevier Science Ltd. All rights reserved.