SYNTHESIS OF THE NOVEL ANTIDEPRESSANT (R)-(-)-ROLIPRAM

Authors
LANGLOIS N WANG HS
Citation
N. Langlois et Hs. Wang, SYNTHESIS OF THE NOVEL ANTIDEPRESSANT (R)-(-)-ROLIPRAM, Synthetic communications, 27(18), 1997, pp. 3133-3144
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
18
Year of publication
1997
Pages
3133 - 3144
Database
ISI
SICI code
0039-7911(1997)27:18<3133:SOTNA(>2.0.ZU;2-9
Abstract
Enantioselective synthesis of (R)-Rolipram 1 has been achieved through a conjugate addition of cyanide to enantiomerically pure 2-(2-aryl et henyl)oxazoline 2, followed by selective reduction of the adduct with NaBH4-NiCl2.