Symptomatic and syndromal anxiety and depression

The diagnosis of anxiety disorders and major depression can be reliably mad e based on signs and symptoms. However there are significant limitations to the current system of classification including overlapping criteria, high comorbidity, and the issue of subthreshold syndromes. The literature on tre atment response documents that selective serotonin reuptake inhibitors are effective in the treatment of the various anxiety disorders, including when comorbid major depression is present. The literature also suggests that tr icyclic antidepressant medications have superior benefits over selective se rotonin reuptake inhibitors in major depression. Examination of the functio nal anatomy of the fear and reward systems may shed light on the underlying processes in the anxiety and depressive disorders. Such an approach points out the importance of addressing avoidance behaviors, which may be more re sponsive to cognitive behavioral treatments than pharmacological agents. (C ) 2001 Wiley-Liss, Inc.