MECHANISTICALLY-BASED HUMAN HAZARD ASSESSMENT OF PEROXISOME PROLIFERATOR-INDUCED HEPATOCARCINOGENESIS

Authors
ASHBY J BRADY A ELCOMBE CR ELLIOTT BM ISHMAEL J ODUM J TUGWOOD JD KETTLE S PURCHASE IFH
Citation
J. Ashby et al., MECHANISTICALLY-BASED HUMAN HAZARD ASSESSMENT OF PEROXISOME PROLIFERATOR-INDUCED HEPATOCARCINOGENESIS, Human & experimental toxicology, 13, 1994, pp. 1-117
Citations number
471
Categorie Soggetti
Toxicology
Journal title
Human & experimental toxicology → ACNP
ISSN journal
09603271
Volume
13
Year of publication
1994
Supplement
2
Pages
1 - 117
Database
ISI
SICI code
0960-3271(1994)13:<1:MHHAOP>2.0.ZU;2-5
Abstract
The conclusion of this review is that peroxisome proliferators constit ute a discrete class of nongenotoxic rodent hepatocarcinogens and that the relevance of their hepatocarcinogenic effects for human hazard as sessment is considered to be negligible.