Background. Living donors provide the best outcome for children underg
oing renal transplantation. Most of these donors are parents. When par
ents are unable to donate, siblings are often considered. But what if
the siblings are also children? Should they be permitted to donate? Me
thods. To see how this difficult ethical question is currently handled
, a survey was mailed to all U.S. renal transplant centers asking for
their policies regarding kidney donation by miners (<18 years old). Re
sults. Among the 117 responding centers that offer pediatric transplan
tation, the vast majority (81%) prefer living related donors for pedia
tric recipients. Yet, only 33% of responding centers would allow a mon
ozygotic twin minor to donate a kidney to his or her twin, and even fe
wer (21%) would allow a nontwin minor to donate to a sibling. In the y
ear before the survey, only two of these centers had actually used a c
hild as a kidney donor. Furthermore, the great majority of responding
centers (68%) require living donors to be at least 18 years old. Concl
usions. These data indicate that most U.S. transplant centers are oppo
sed to using children as living kidney donors. On the other hand, a ca
reful analysis of this issue suggests that although donation by a mino
r should be uncommon, a complete ban of this practice may be unwarrant
ed. In unusual circumstances in which no other suitable donor is avail
able, consenting mature miners, and even rare immature miners who are
highly likely to benefit from donating, may be ethically acceptable. A
lthough there are probably no absolute wrong or right answers, the que
stion of kidney donation by children should be readdressed.