Hemodynamic analysis of esophageal varices using color Doppler endoscopic ultrasonography to predict recurrence after endoscopic treatment

Background and Study Aims: The time to recurrence of esophageal varices may vary greatly between patients even after the same endoscopic therapy. To c larify the factors which contribute to recurrence after endoscopic treatmen t, the hemodynamics and morphology of the left gastric vein (LGV) were inve stigated using color Doppler endoscopic ultrasonography (EUS). Patients and Methods: A total of 31 patients with high-risk esophageal vari ces underwent color Doppler-EUS before receiving endoscopic variceal ligati on and endoscopic injection sclerotherapy combined therapy. Endoscopic exam ination was performed every 3 months after the treatment to evaluate recurr ence of varices. Results: A total of 18 patients responded to the therapy, while 13 patients did not respond, and had recurrence within 12 months. The hepatofugal flow velocity in the LGV trunk was significantly lower in the responders (9.9 v s. 13.9 cm/sec; P=0.02). The branch pattern of the LGV was categorized into three groups: anterior branch dominant, posterior branch dominant, and no- dominant type. The incidence of the anterior branch dominant type was signi ficantly less in responders (17 vs. 70%; P=0.01). There was no significant difference in the LGV trunk diameter and the size of the paraesophageal vei n between the two groups. Conclusion: Risk factors for recurrence can be analyzed in detail using col or Doppler-EUS. Further investigation using color Doppler-EUS may enable us to select the optimal way to treat esophageal varices to prevent recurrenc e.