Danazol therapy in factor X deficiency

Factor X (FX) deficiency is a rare coagulation disorder that usually presen ts with bleeding manifestations and is treated with fresh frozen plasma or prothrombin complex concentrates. We report a case of FX deficiency in whic h the patient presented with bleeding as well as thrombosis. The patient re sponded to Danazol and relapsed when the drug was stopped. The occurrence o f thrombosis in FX deficiency and the role of Danazol in coagulopathies are reviewed.