Novel basic isoflavones as inhibitors of bone resorption

A number of aminoalkoxy analogues of ipriflavone (=7-(1-methylethoxy)isofla vone) were prepared and examined for their capacity to inhibit bone resorpt ion induced by bovine parathyroid hormone fragment 1 - 34. Good-to-high act ivities were found for 7-(aminoalkoxy)isoflavone. analogues. Their activity was influenced by a number of structural features, among which the length of the basic side chain, the basicity of the amino group, and the nature an d position of substituents on the 3-phenyl ring. 4'-(Aminoalkoxy)ipriflavon e derivatives were less active.