EFFECTS OF CENTRAL OXYTOCIN ADMINISTRATION ON INTRAORAL INTAKE OF GLUCOSE IN DEPRIVED AND NONDEPRIVED RATS

We evaluated the effects of lateral intracerebroventricular administra tion of oxytocin (OT) and/or a selective oxytocin-receptor antagonist (OTX), 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-OT, on ingestion of intraor ally delivered 12.5% glucose in rats that were either nondeprived or d eprived of food for 20 h. In deprived rats, OT delivered 30 min before an initial intake test yielded a dose-related reduction of intraoral glucose intake. The highest dose tested, 20 nmol, reduced intraoral gl ucose intake by 45%. The effect was short-lived, however. Intraoral in take for a second test, initiated 60 min after the termination of the first, increased as a function of OT dose so that total session intake was unaffected by OT treatment. The suppression of intraoral intake b y 20 nmol OT was reversed by pretreatment (45 min before testing) with OTX. In nondeprived rats, by contrast, OT yielded no effect on first- test, second-test, or total session intakes. Significant increases in first-test and total session intakes were obtained when OTX (20 nmol) was administered alone both in deprived (32% increase in first-test in take) and nondeprived (31% increase) rats. In general, the results obt ained are consistent with the suggestion that OT contributes to the co ntrol of meal size and, in particular, to the process of satiation, wh ich is the aspect of ingestive control highlighted by the specialized intake test used in the present study. (C) 1997 Elsevier Science Inc.