Primary adenocarcinoma of the vagina arising in endocervicosis

Endocervicosis is a rare condition, being one of the triad of nonneoplastic secondary mullerian lesions. This report describes a primary vaginal adeno carcinoma arising in endocervicosis. Histologic examination showed a mucin- secreting adenocarcinoma admixed with benign mucin-containing endocervical- type glands with a transition from dysplastic glands to obvious adenocarcin oma. There were bilateral groin lymph node metastases at presentation and t he tumor recurred locally 9 and 12 months after treatment. This is the seco nd reported case of vaginal endocervicosis and the first documented report of adenocarcinoma arising in endocervicosis at any site.