Determination of clopidal residues in chicken tissues by liquid chromatography: Part II. Distribution and depletion of clopidal in chicken tissues

A study was made of the distribution and depletion of clopidol residues at different tissue locations in chickens fed with feeds incurred with clopido l. Experiments showed that the residue levels were not identical at 5 diffe rent tissue locations in each chicken. The sequence of residue levels from high to low was livers, kidneys, upper breast, lower breast, and leg meat. The maximum residue values after suspension of the drug for 8 h were (mg/kg ): livers, 4.600; kidneys, 3.619; upper breast, 1.742; lower breast, 1.641; leg meat, 1.525. The averages were taken after values for 10 chickens were determined. After suspension of the drug for 3 days, > 80% residue clopido l was depleted, and the depletion was nearly completed within 7 days. The s peed of depletion varied at different tissue locations in each chicken, wit h the sequence from fast to slow being equivalent to that of the residue le vels. Analytical results of 350 samples during 7 days showed that the propo sed method is specific for determination of clopidol in chickens.